Table 3. Microbiology and antimicrobial treatment of patients with nontuberculous mycobacterial musculoskeletal infections, Colorado, USA*.
| Patient no. | Species | Oral therapy (duration, mo) | Intravenous therapy (duration, mo) | Total duration of therapy, mo | Time from last surgery to cessation of antimicrobial therapy, mo | Outcome |
|---|---|---|---|---|---|---|
| 1 | M. abscessus | Azithromycin (24) | Tigecycline + amikacin + imipenem (24) | 24 | 0 | Cured |
| 2 | M. abscessus | Azithromycin + linezolid (6) | Amikacin + imipenem (6) | 6 | 0 | Cured |
| 3 | M. abscessus | Azithromycin + clofazimine (20) | Imipenem + amikacin (15) | 20 | 0 | Cured |
| 4 | M. abscessus | Azithromycin + clofazimine (14) | Cefoxitin + amikacin (8) | 14 | 0 | Cured |
| 5 | M. fortuitum | Moxifloxacin (2) | Imipenem (2) | 2 | 1 | Cured |
| 6 | M. fortuitum | Doxycycline + ciprofloxacin + trimethoprim/ sulfamethoxazole (5) | Amikacin (3) | 5 | 3 | Cured |
| 7 | M. massiliense | Azithromycin, linezolid (4) | Cefoxitin, tigecycline, linezolid, amikacin, azithromycin (4) | 4† | NA | Treatment failure |
| 8 | M. intracellulare | Azithromycin + ethambutol + rifabutin (14) | Amikacin (8) | 14 | 1 | Cured |
| 9 | MAC, speciation unavailable | Azithromycin + clofazimine + ethambutol + rifampin (39) | Amikacin (2) | 39 | 11 | Cured |
| 10 | M. intracellulare | Azithromycin + rifampin + clofazimine + ethambutol (27) | Amikacin (5) | 27 | 7 | Cured |
| 11 | M. intracellulare | Azithromycin + moxifloxacin + ethambutol (9) | None | 9 | 5 | Cured |
| 12 | MAC, speciation unavailable | Azithromycin + ethambutol + rifampin (7) | None | 7 | 3 | Cured |
| 13 | M. gordonae | Azithromycin + trimethoprim/ sulfamethoxazole + ethambutol (16) | Amikacin (2) | 16 | 2 | Cured |
| 14 | M. marinum | Azithromycin + ciprofloxacin (14) | Imipenem (10) | 14 | 10 | Cured |
*All bacteria are Mycobacterium spp. MAC, Mycobacterium avium complex. †Patient elected to discontinue antimicrobial treatment after experiencing intolerable side effects from multiple medications, despite ongoing disseminated infection.