Figure 5. Relationship of Δ age to clinical variables.

(A–I) Representative plots are shown using raw data (A–I). P values were determined by linear regression with relevant covariates. (A) Postmortem final clinical diagnosis of AD, (B) mini mental examination score, (C) tangles density, (D) Global PD score, a composite score for 4 signs: tremor, rigidity, bradykinesia, and gait, (E) rigidity score, (F) PD pathology is present if Lewy bodies are present and there was moderate-to-severe neuronal loss in the substantia nigra, (G) Global cognition slope, a composite slope of the longitudinal changes over time in five domains of cognition: working memory, visual-spatial ability, perceptual speed, episodic memory, and semantic memory, (H) change in episodic memory over time, and (I) association of Δ age & APOE ε4.