Table 2.

False discovery corrected P-values obtained from regression of either Δ age (main method) or APOE ε4 with indicated disease or aging variables of interest.

Variable	Δ Age	APOE ε4
	P-value	P-value
ΔGlobal cognition/yr	5.1 × 10−5a	1.9 × 10−5a
ΔEpisodic memory/yr	2.9 × 10−4a	2.5 × 10−6a
ΔVisual-spatial ability/yr	0.003a	0.02a
ΔPerceptual speed/yr	8.7 × 10−5a	0.02a
ΔSemantic memory/yr	5.1 × 10−5a	1.6 × 10−5a
ΔWorking memory/yr	0.03a	0.006a
Global cognition level	3.2 × 10−5a	2.4 × 10−6a
Episodic memory level	9 × 10−5a	2.2 × 10−6a
Dementia grade	0.006a	7.6 × 10−5a
AD clinical diagnosis	3.2 × 10−5a	7.9 × 10−4a
Mini mental examination score	0.0017a	1.7 × 10−4a
Depression score	0.69	0.85
General pathology	0.035a	5.2 × 10−10a
Plaque level	0.06	8.1 × 10−8a
Tangles level	0.04a	5.4 × 10−7a
Amyloid level	0.15	5.4 × 10−7a
Amyloid angiopathy	0.07a	9.4 × 10−7a
PD diagnosis	0.88	0.28
PD sign score	0.038a	0.02a
Gait	0.031a	0.02a
Bradykinesia	0.41	0.02a
Rigidity	0.0059a	0.035a
Tremor	0.86	0.17
PD Pathology	0.006a	0.88
Lewy body pathology	0.02a	0.69
Stroke diagnosis	0.56	0.40
“Heart problem” history	0.17	0.90
Hypertension at baseline	0.003b	0.67
Arteriolar sclerosis	0.75	0.84
Cerebral infarction gross	0.47	0.40
Cerebral infarction micro	0.33	0.58
Cancer history	0.91	0.95
Thyroid disease history	0.08	0.60
Smoking (lifetime pack-years)	0.75	0.46
APO ε4 alleles	0.035a	0
Δ Age	0	0.035a

^aIndicate significantly increased risk with older Δ age or greater APOE ε4 alleles.

^bIndicates the inverse relationship.