Table 2. Cox Proportional Hazards Regression of Clinicopathologic Factors Associated With Mortality.
| Factor | HR (95% CI) | |
|---|---|---|
| Univariable | Multivariable | |
| Age | 1.0 (1.00-1.04) | NA |
| Female vs male | 0.8 (0.4-2.0) | NA |
| Smoking >20 pack-years | 1.1 (0.5-2.3) | NA |
| ACE-27 score | ||
| None to mild | 1 [Reference] | Not included in final model |
| Moderate to severe | 1.8 (1.1-3.1) | |
| Location | ||
| Tonsil | 1 [Reference] | NA |
| Base of tongue | 1.1 (0.6-1.8) | NA |
| Soft palate | 2.5 (0.9-7.2) | NA |
| T3-T4 vs T1-T2 | 2.4 (1.4-4.0)a | Not included in final model |
| N0-N1 | 1 [Reference] | NA |
| N2a-N2b | 0.7 (0.4-1.3) | NA |
| N2c-N3 | 1.4 (0.8-2.6) | NA |
| Poorly differentiated vs well or moderately differentiated | 0.5 (0.3-0.9)a | Not included in final model |
| Surgery-PORT vs definitive CRT | 0.6 (0.4-1.0)a | 0.3 (0.1-0.6)a |
| Chemotherapy | ||
| None | 1 [Reference] | NA |
| Concurrent | 1.1 (0.6-1.9) | NA |
| Induction and concurrent | 1.7 (0.9-3.3) | NA |
| Baseline ALC | 0.9 (0.7-1.3) | NA |
| Nadir ALC | 0.9 (0.1-6.3) | NA |
| Nadir grade 3-4 lymphopenia | 0.8 (0.3-1.9) | NA |
| 3-mo post-RT ALC | 0.5 (0.2-1.2) | NA |
| 3-mo post-RT grades 3-4 lymphopenia | 2.2 (1.1-4.3)a | 2.6 (1.3-5.5)a |
| 6-mo post-RT ALC | 0.3 (0.1-0.9)a | Not included in final model |
| 6-mo post-RT grades 3-4 lymphopenia | 1.6 (0.6-4.3) | NA |
| 12-mo post-RT ALC | 0.2 (0.1-0.7)a | Not included in final model |
| 12-mo post-RT grades 3-4 lymphopenia | 1.4 (0.3-6.3) | NA |
| Pretreatment NLR | 1.0 (1.00-1.08) | NA |
| ALC nadir NLR | 1.00 (0.99-1.01) | NA |
| 3-mo post-RT NLR | 1.07 (1.01-1.13)a | Not included in final model |
| 6-mo post-RT NLR | 1.02 (0.97-1.07) | NA |
| 12-mo post-RT NLR | 1.06 (1.02-1.09)a | Not included in final model |
| Second cancer after RT | 0.8 (0.4-1.5) | NA |
Abbreviations: ACE, Adult Comorbidity Evaluation 27; ALC, absolute lymphocyte count; CRT, chemoradiotherapy; NA, not applicable; NLR, ratio of neutrophils to lymphocytes; PORT, postoperative radiotherapy; RT, radiotherapy.
a
Indicates significance.