Table. Baseline Characteristics in Patients With No Events, Single Event, or Multiple Events in Pooled Randomization Groups.
| Characteristic | Event, No. (%) | P Value (1 vs ≥2 Events)a | ||
|---|---|---|---|---|
| None (n = 24 657) | 1 (n = 1574) | Multiple (n = 1333) | ||
| Male | 18 498 (75.0) | 1261 (80.1) | 1036 (77.7) | .11 |
| White | 20 944 (84.9) | 1354 (86.0) | 1160 (87.0) | .43 |
| Age, mean (SD), y | 62.5 (9.0) | 63.0 (9.1) | 62.1 (9.2) | .01 |
| Region | ||||
| North America | 3900 (15.8) | 322 (20.5) | 349 (26.2) | <.001 |
| Europe | 15 591 (63.2) | 945 (60.0) | 799 (59.9) | |
| Latin America | 1651 (6.7) | 112 (7.1) | 60 (4.5) | |
| Asia | 3515 (14.3) | 195 (12.4) | 125 (9.4) | |
| Type of atherosclerosis | ||||
| Myocardial infarction | 19 845 (80.5) | 1326 (84.2) | 1180 (88.5) | <.001 |
| Nonhemorrhagic stroke | 4778 (19.4) | 341 (21.7) | 218 (16.4) | <.001 |
| Peripheral artery disease | 3168 (12.8) | 256 (16.3) | 218 (16.4) | .95 |
| Time from MI to randomization, No./total No. (%), y | ||||
| <1 | 4980/19 817 (25.1) | 355/1324 (26.8) | 376/1179 (31.9) | .02 |
| 1 to <2 | 2374/19 817 (12.0) | 169/1324 (12.8) | 148/1179 (12.6) | |
| ≥2 | 12 463/19 817 (62.9) | 800/1324 (60.4) | 655/1179 (55.6) | |
| History, No./total No. (%) | ||||
| Hypertension | 19 649/24 656 (79.7) | 1322 (84.0) | 1113 (83.5) | .72 |
| Diabetes | 8826 (35.8) | 670 (42.6) | 585 (43.9) | .47 |
| Current smoker | 7025/24 655 (28.5) | 385 (24.5) | 367 (27.5) | .06 |
| History CHF | 5594 (22.7) | 442 (28.1) | 358 (26.9) | .46 |
| eGFR, mean (SD), mL/min/1.73m2 | 76.0 (18.7) | 73.8 (20.2) | 73.8 (19.8) | .87 |
| Statin intensity at baseline | ||||
| None/low/unknown | 60 (0.2) | 8 (0.5) | 1 (0.1) | .11 |
| Moderate | 7578 (30.7) | 437 (27.8) | 377 (28.3) | |
| High | 17 019 (69.0) | 1129 (71.7) | 955 (71.6) | |
| Ezetimibe use at baseline | 1246 (5.1) | 105 (6.7) | 89 (6.7) | >.99 |
| Lipid measures, median (IQR), mg/dL | ||||
| LDL cholesterol | 92 (80-108) | 92 (81-110) | 95 (82-113) | .007 |
| Total cholesterol | 168 (151-188) | 167 (150-188) | 170 (153-192) | .006 |
| HDL cholesterol | 44 (37-53) | 43 (36-51) | 43 (36-51) | .98 |
| Triglycerides | 133 (100-182) | 138 (102-182) | 136 (103-186) | .60 |
Abbreviations: HDL, high-density lipoprotein; IQR, interquartile range; LDL, low-density lipoprotein.
SI conversion factor: To convert cholesterol levels to millimoles per liter, multiply by 0.0259; triglycerides to millimoles per liter, multiply by 0.0113.
a
For 3-way comparison, all P < .005 except age (P = .04), white race (P = .07), and triglycerides (P = .03).