Table 2.
General recommendations and challenges for DSC- and DCE-MRI in various neuropathologies
| Neuro-oncology | Stroke | Aging | Multiple Sclerosis | |
|---|---|---|---|---|
|
|
||||
| DSC and DCE Acquisition | High temporal resolution Low spatial resolution |
Moderate temporal resolution Moderate spatial resolution |
Low temporal resolution High spatial resolution |
Low temporal resolution High spatial resolution |
| Potential pitfalls | CA leakage effects | CA delay AIF identification |
Diffuse pathology Long scan times |
Focal and diffuse characteristics Long scan durations |
| DSC and DCE Parameters (Basic) | rCBV Ktrans |
MTT and Tmax Ktrans |
rCBV Ktrans |
rCBF and rCBV Ktrans |
| DSC and DCE Parameters (Advanced) | VAI CTH Water exchange |
OEFmax CTH |
VAI CTH |
Temporal and spatial patterns of perfusion and BBB permeability |