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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Anesthesiology. 2019 Feb;130(2):247–262. doi: 10.1097/ALN.0000000000002529

Fig.7.

Fig.7.

Treatment with NO donor prevents the negative effect of ISO and PDZ2WT peptide on hippocampal LTP. A, robust LTP was induced by HFS in all groups. In upper left quadrants example traces of WT CON+NO and WT ISO+NO (top), PDZ2MUT+NO and PDZ2WT+NO (bottom) treated groups before HFS (solid line trace) and 55-60min after HFS (dashed line trace) are shown. B, the median of normalized fEPSP 55-60min after HFS no longer shows a significant difference between WT CON and WT ISO when NO donor is added (WT CON + NO (n=5) vs ISO + NO (n=8), p=0.284) or between PDZ2MUT and PDZ2WT (PDZ2MUT + NO (n=5) vs PDZ2WT + NO (n=6), p=0.662). Data were analyzed with Mann-Whitney tests. Data from individual animals are plotted and color coded by gender (red=female and blue=male). Data were plotted as median and interquartile range. Values were considered significant at *p < 0.05 or less. Scale bar: 10ms, 0.25mV.