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Chemical structures of polyamine analogs and their polymeric prodrugs. BENSpm, PG11047, DSS-BEN, and DSS-PG. Chemical structure of a first-generation polyamine analogue, BENSpm (A), a second-generation polyamine analogue PG-11047 (B), polyamine drugs DSS-BEN (C), and DSS-PG (D) derived from parental drugs, respectively.
