. Author manuscript; available in PMC: 2020 May 1.

Published in final edited form as: Radiat Res. 2019 Mar 22;191(5):383–397. doi: 10.1667/RR15130.1

TABLE 1.

Wall Characteristics of Coronary Arteries

	Nonirradiated, age-matched controls				TBI
Time post-TBI:	4 months	6 months	13 months	18 months	4 months	6 months	13 months	18 months
No. intimal nuclei	19.5 ± 2.28	20.3 ± 3.04	20.4 ± 2.30	24.7 ± 0.44	11.3 ± 1.18	14.5 ± 2.39	9.9 ± 1.83	10.3 ± 1.28
Luminal diameter (μm)	133 ± 12.1	140 ± 15.7	123 ± 11.4	155 ± 11.3	138 ± 12.5	162 ± 6.2	143 ± 13.2	159 ± 14.3
Luminal perimeter (μm)	417 ± 37.9	510 ± 49.4	386 ± 35.8	485 ± 35.5	434 ± 39.3	510 ± 19.4	449 ± 41.6	499 ± 35.5
No. medial nuclei	18.2 ± 3.96	16.4 ± 1.82	13.9 ± 0.83	20.2 ± 0.44	14.4 ± 2.93	16.8 ± 2.77	12.7 ± 2.18	13.5 ± 2.81
Medial area (μm²)	4,090 ± 591	4,440 ± 705	4,300 ± 486	7,676 ± 1,274	3,980 ± 807	5,680 ± 430	5,580 ± 597	7,620 ± 1,844
Medial thickness (μm)	9.66 ± 0.56	9.93 ± 0.62	10.5 ± 0.63	15.6 ± 1.66	8.67 ± 0.96	11.1 ± 0.58	12.2 ± 0.76	14.6 ± 2.20
Medial collagen (μm²)	536 ± 60	1,164 ± 91	1,133 ± 73	2,250 ± 384	1,108 ± 269	1,829 ± 218	2,422 ± 362	4,297 ± 845
Adventitial collagen (μm²)	1,462 ± 120	1,612 ± 169	2,875 ± 235	4,599 ± 909	2,341 ± 250	2,374 ± 236	3,986 ± 1,445	5,712 ± 813

Notes. Individual mouse averages were obtained from two cross sections of the left coronary artery. n = 4 for each group and time from 4–13 months post-TBI; n = 3 for nonirradiated and n = 5 for TBI at 18 months post-TBI.