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. 2019 May 28;14(5):e0216300. doi: 10.1371/journal.pone.0216300

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© 2019 Traitanon et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — Based on the differentially expressed genes, certain functions like inflammatory response, chemotaxis of T lymphocytes, and growth of connective tissue were predicted to be inhibited (blue). IPA analysis predicted that the inhibition of upstream regulators like the cytokine TGFB1, EDN1, IL-6 and OSM would lead to decrease in the functions listed in the third tier of the figure via their effect on the mediator genes that were also seen to be differentially expressed between the two groups. Please see Table H in S5 File for complete information.