Table 3. Results– 12 month histopathology data.
| Pathology | TAC+EVR (n = 19)* | TAC+MMF (n = 16)* |
|---|---|---|
| Glomerusclerosis:-Global (GS) and Segmental (SS) | GS: 8 (42%) | GS: 5 (33%) |
| SS: 5 (26%) | SS: 4 (27%) | |
| Acute glomerulitis (g) | g1: 0 (0%) | g1: 2 (13%) |
| g2: 0 (0%) | g2: 0 (0%) | |
| g3: 0 (0%) | g3: 0 (0%) | |
| Tubulitis NOT in IFTA (>t) | t1: 1 (5%) | t1: 2 (13%) |
| t2: 2 (11%) | t2: 1 (6%) | |
| t3: 0 (0%) | t3: 0 (0%) | |
| Acute Tubular Necrosis (ATN)/Isometric Tubular vacuolization | Mild: 14 (74%) | Mild: 9 (56%) |
| Moderate: 5 (26%) | Moderate: 1 (6%) | |
| Severe: 0 (0%) | Severe: 0 (0%) | |
| Isometric: 1 (5%) | ||
| Interstitial Inflammation (i) | i1: 1 (5%) | i1: 2 (12%) |
| i2: 0 (0%) | i2: 0 (0%) | |
| i3: 0 (0%) | i3: 0 (0%) | |
| Arteriolar Hyalinosis (ah) | ah1: 1 (5%) | ah1: 1 (6%) |
| ah2: 0 (0%) | ah2: 0 (0%) | |
| ah3: 0 (0%) | ah3: 0 (0%) | |
| Arteriosclerosis (cv) | cv1: 5 (26%) | cv1: 4 (25%) |
| cv2: 1 (5%) | cv2: 0 (0%) | |
| cv3: 0 (0%) | cv3: 0 (0%) | |
| Peritubular capillaritis (PTC) | ptc1: 0 (0%) | ptc1: 3 19%) |
| ptc2: 0 (0%) | ptc:2: 2 (13%) | |
| ptc3: 0 (0%) | ptc:3: 0 (0%) | |
| Interstitial fibrosis and Tubular atrophy (IFTA)** | Mild: 12 (63%) | Mild: 11 (70%) |
| Moderate: 1 (5%) | Moderate: 1 (6%) | |
| Severe: 0 (0%) | Severe: 0 (0%) | |
| Inflammation associated with IFTA | Minimal: 4 (21%) | Minimal: 1 (6%) |
| Mild: 5 (26%) | Mild: 4 (25%) | |
| Moderate: 3 (16%) | Moderate: 3(20%) | |
| Severe: 0 (0%) | Severe: 0 (0%) | |
| Tubulitis of intact tubules within/interface (t) | t1: 4 (21%) | t1: 3 (20%) |
| t2: 2 (11%) | t2: 1 (6%) | |
| t3: 0 (0%) | t3: 0 (0%) | |
| Transplant glomerulopathy (cg) | cg1: 0 (0%) | cg1:0 (0%) |
| cg2: 0 (0%) | cg2:0 (0%) | |
| cg3: 0(0%) | cg3: 0 (0%) | |
| C4d staining on immunofluorescence | C4d1: 0 (0%) | C4d1: 0 (0%) |
| C4d2: 0 (0%) | C4d2: 0 (0%) | |
| C4d3: 0 (0%) | C4d3: 4(25%) | |
| OTHER FINDINGS/DIAGNOSIS | Borderline change:2 (12%) | Borderline change: 2/15 (13%) |
| Subcapsular injury: 5 (30%) | Subcapsular injury: 2/15 (13%) | |
| Polyoma Virus: 1/15 (7%) | ||
| AMR: 4/15 (27%) |
* All values expressed as n (%). There was no significant difference between the 2 study groups. All pathological definitions are per Banff criteria. Please see Table B in S4 Data file for complete information.
** IFTA0 and IFTA1 combined in one group.