Table 1.
Demographic and clinical data of patients with Alzheimer’s disease grouped based on APOE-ε4 carriers versus non-carriers or FGF1-rs34011-GG (GG-carriers) versus FGF1-rs34011-A-allele carriers (A-allele-carriers).
| APOE-ε4 carriers | APOE-ε4 non-carriers | P value | GG-carriers | A-allele- carriers |
P value | |
|---|---|---|---|---|---|---|
| Sample size (n) | 38 | 59 | 48 | 49 | ||
|
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| Age (years) | 71.2±7.3 | 71.7±8.1 | 0.765 | 71.1±8.5 | 71.9±7.0 | 0.597 |
|
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| Sex (% male) | 47.4% | 59.3% | 0.248 | 58.3% | 51.0% | 0.469 |
|
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| Education (years) | 8.0±2.3 | 8.7±4.9 | 0.502 | 8.6±4.9 | 8.2±5.3 | 0.701 |
|
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| MMSE | 21.2±5.7 | 22.1±6.1 | 0.449 | 21.0±6.6 | 22.5±5.1 | 0.204 |
|
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| CDR | 0.6±0.3 | 0.5±0.2 | 0.282 | 0.58±0.28 | 0.53±0.24 | 0.319 |
|
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| Episodic memory scores | ||||||
|
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| CVVLT-30 s | 4.2±2.8 | 5.1±2.6 | 0.133 | 4.6±2.7 | 4.9±2.7 | 0.497 |
| CVVLT-10 min | 2.7±3.3 | 4.2±3.1 | 0.034 | 3.5±3.3 | 3.8±3.2 | 0.567 |
| CVVLT-cued | 3.6±3.2 | 4.9±2.6 | 0.033 | 4.3±3.0 | 4.6±2.9 | 0.637 |
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| TIV (liter) | 1.4±0.1 | 1.4±0.2 | 0.822 | 1.3±0.2 | 1.4±0.1 | 0.551 |
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| TIV adjusted volume *10-3 | ||||||
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| Left hippocampus | 1.0±0.2 | 1.2±0.2 | 0.001 | 1.1±0.2 | 1.2±0.2 | 0.356 |
| Right hippocampus | 1.1±0.3 | 1.3±0.2 | 0.008 | 1.2±0.3 | 1.3±0.2 | 0.106 |
Data are presented as mean ± standard deviation; P value denotes significant differences between groups on independent t-test for continuous, and χ2 test for dichotomous variables. CDR, Clinical Dementia Rating; CVVLT, Chinese version of the Verbal Learning Test (CVVLT-30 s: words recalled after 30 seconds; CVVLT-10 min: words recalled after 10 minutes; CVVLT-cued: words recalled with cued procedures); APOE, apolipoprotein E; FGF1, fibroblast growth factor 1; MMSE, Mini-Mental State Examination; TIV, total intracranial volume.