Figure 1. Isoforms of glutaminase have opposing roles in cancer metastasis.
Glutaminase 1 increases tumor cell survival via its canonical catalytic activity. Opposingly glutaminase 2 inhibits tumor metastasis and EMT via its secondary functions as a binding protein (Details in text). EMT (Epithelial-Mesenchymal Transition); Rac1 (Ras-related C3 botulinum toxin substrate 1)