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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Clin Exp Metastasis. 2019 May 9;36(3):211–224. doi: 10.1007/s10585-019-09967-0

Figure 4. Altered metabolism impacts regulation of cancer epigenome via production of substrates and allosteric regulators of epigenetic enzymes.

Figure 4.

IDH mutations can produce 2-hydroxyglutarate which alter the function of demethylase enzymes. In addition, altered metabolism has been linked to changes in production of Acetyl-CoA the substrate of histone acetyltransferases. HAT (Histone Acetyltransferase); HDAC (Histone Deacetylase); mIDH (mutant IDH); Ac (Acetylation)