Figure 3. Cisplatin reduces mitophagy in vivo which NMN counteracts.

(A) Schematic depicting experimental interventions in mtKeima Tg mice. (29. AUTHOR: Query 28.) (B–J) Renal cortex of mtKeima mice treated with vehicle or cisplatin (20 mg/kg i.p., 72 hours) ± NMN (400 mg/kg i.p. as indicated). Scale bars: 50 μm. (K) Quantification of mitophagy index for B–J relative to control condition. n = 12 fields from 3 mice per condition. P value calculated by ANOVA on biological replicates.