Figure 10. UPR-related genes are upregulated in the airways of human patients with asthma.

(A) RT-qPCR analysis of ATF6α-related genes from lung tissue. n = 10 healthy and n = 20 asthmatic subjects. Mann-Whitney U test, P values versus healthy subjects. (B and C) Correlation plot of the relative expressions of PDIA5 and RABAC1 to blood eosinophils and bronchodilator response (measured as change in absolute FEV1 relative to baseline). Spearman’s rank correlation coefficient (r_s) of the group with asthma (healthy subjects excluded). P < 0.05 is considered significant. Error bars represent ± SD.