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. 2019 May 2;4(9):e98101. doi: 10.1172/jci.insight.98101

Figure 5. CBAs attenuate HDM-induced AHR, IL-4, IL-5, IL-13, and IgE production.

Figure 5

(A–C) AHR measurement by FlexiVent in response to 50 mg/ml methacholine. One-way ANOVA and Tukey’s post hoc test for Rn and Kruskal-Wallis and 2-stage linear step-up procedure of Benjamini, Krieger, and Yekutiel post hoc test for G and H. *P < 0.05 vs. PBS plus DMSO mice; #P < 0.05 vs. HDM plus DMSO mice. PBS plus DMSO n = 10; HDM plus DMSO n = 13; and βM/GM/AβM/GnβM plus HDM n = 7 from 2 experiments (mice were removed based on noncompliance with COD value in Rn/G/H βM: n = 1; AβM: n = 1). (D–H) Quantification of cytokines by ELISA from lung homogenates and IgE from serum. PBS and HDM plus DMSO n = 6 mice/group from 2 experiments; HDM plus TCCA/βM/GβM/AM/GnβM n = 10 mice/group from 2 experiments (outliers removed in various groups; IL-4: PBS plus DMSO n = 1; IL-5: HDM plus DMSO n = 1). Kruskal-Wallis, 2-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli. Six comparisons, all with the HDM plus DMSO group. *P < 0.05 vs. PBS plus DMSO group; #P < 0.05 vs. HDM plus DMSO group; ns, not significant. Error bars represent ± SEM.