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. 2019 May 2;4(9):e98101. doi: 10.1172/jci.insight.98101

Figure 6. TUDCA does not activate the FXR or TGR5 pathways in an allergen-induced model of asthma.

Figure 6

(A) Illustration of mediators regulated downstream of canonical bile acid receptors FXR and TGR5. (B) Gene expression quantified by RT-qPCR from the lungs. One-way ANOVA, Tukey’s post hoc test. *P < 0.05 vs. PBS; #P < 0.05 vs. HDM plus PBS mice. n = 6–10 mice/group from 2 experiments (outliers removed, Nr0b2 in HDM plus TUDCA, n = 1). HK, housekeeping; ns, not significant. Error bars represent ± SEM.