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. 2019 Apr 18;4(8):e126747. doi: 10.1172/jci.insight.126747

Figure 4. Topographic distributions of cones and blood-retina barrier failure following loss of rods.

Figure 4

(A) In rd10 mice, at P35–P40, cone densities (arrestin, green) were lower in the areas with vascular leak (albumin, blue). (B–D) Magnified areas from A. In WT mice, cones were evenly distributed through the retina; no albumin labeling was detected outside of the capillaries (B). In rd10 mice, regions with leak and degenerating deep layer capillaries corresponded to lower densities of cones. (E) Quantification of cone-occupied areas across retinal poles. (F) Mander’s indices show that areas with surviving cones and leaky areas do not overlap. (G) Leak was determined predominantly in the central areas at the level of retinal pigment epithelium. Scale bar: 1 mm (A); 50 μm (B–D). Data are represented as average ± SD (8 mice, each measurement). Two-tailed t test, *P < 0.05, **P < 0.01. PLVAP, plasmalemma vesicle-associated protein.