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. 2019 May 2;4(9):e124747. doi: 10.1172/jci.insight.124747

Figure 1. SIRPα deficiency results in an age-dependent onset of proteinuria, loss of podocytes, and glomerulosclerosis.

Figure 1

(A) Albumin/creatinine ratio in Sirpa–/– and WT mice at 3, 6, 12, and 20 months (M). (B) Percentages of albuminuria >300mg/l in 20-month-old WT and Sirpa–/– mice (n = 18 WT and n = 20 Sirpa–/– mice; P value was analyzed by Fisher’s exact test). (C) Histology of WT and Sirpa–/– mice at 3, 6, 12, and 20 months (arrows indicate glomerulosclerosis). The histogram represents statistical analysis of sclerosed glomeruli in 20-month WT and Sirpa–/– mice (n = 7 WT mice and n = 7 Sirpa–/– mice; 10–20 glomeruli of each mouse were analyzed). (D) WT1 immunostaining and quantification of WT1-positive glomerular cells in kidneys from 20 months WT and Sirpa–/– mice (glomeruli from n = 6 WT mice and n = 5 Sirpa–/– mice, were analyzed). Scale bars in C and D: 10 μm. Data in A, C, and D represent mean ± SEM, and P value was analyzed by 2-tailed Student’s t test. **P < 0.01.