TABLE 3.
Parameters | At Personal best HbF |
Study month 0 |
Study month 6a |
||||||
---|---|---|---|---|---|---|---|---|---|
Intervention n = 18 |
Control n = 10 |
P value | Intervention n = 18 |
Control n = 10 |
P value | Intervention n = 16 |
Control n = 8 |
P valueb | |
HU dose | 24.9 ± 4.8 | 23.8 ± 4.6 | 0.52 | 25.9 ± 3.9 | 21.7 ± 4.4 | 0.03 | 24.3 ± 7.6 | 22.5 ± 3.5 | 0.11 |
Hb | 8.9 ± 1.6 | 9.1 ± 0.7 | 0.70 | 8.6 ± 1.3 | 9.3 ± 1.3 | 0.25 | 8.9 ± 1.2 | 9.5 ± 1.8 | 0.44 |
MCV | 96.9 ± 11.7 | 101.1 ± 10.2 | 0.35 | 94.5 ± 13.0 | 86.8 ± 30.8 | 0.94 | 98.0 ± 11.3 | 89.0 ± 35.7 | 0.76 |
ARC | 258 ± 181 | 204 ± 69 | 0.76 | 321 ± 183 | 307 ± 141 | 0.94 | 253 ± 133 | 248 ± 143 | 0.71 |
WBC | 10.1 ± 3.8 | 9.1 ± 3.0 | 0.64 | 9.5 ± 2.8 | 10.5 ± 3.8 | 0.54 | 9.0 ± 2.7 | 7.9 ± 2.6 | 0.26 |
ANC | 4.7 ± 2.0 | 4.7 ± 3.0 | 0.60 | 4.5 ± 1.9 | 4.0 ± 1.9 | 0.59 | 3.2 ± 2.0 | 3.6 ± 1.5 | 0.71 |
Platelets | 474 ± 338 | 439 ± 175 | 0.54 | 485 ± 262 | 350 ± 159 | 0.36 | 453 ± 248 | 438 ± 179 | 0.92 |
PB, Personal best HbF.
Intervention group: one withdrawal and one with multiple transfusions; Control group: two withdrawals.
Wilcoxon rank sum. Bold P value means statistical significance.