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. Author manuscript; available in PMC: 2020 May 28.
Published in final edited form as: Biomater Sci. 2019 May 28;7(6):2218–2240. doi: 10.1039/c9bm00238c

Table 1.

The comparison between microfluidic reactors and batch reactors.

Microfluidic Reactors Macroscopic Batch Reactors
Laminar flow Segmented flow
Chip-scale operations Yes Yes No
Tunable parameters Yes, the design of microfluidic reactors and the adjustable flow rate provide flexible reactions No, the only adjustable parameter may be the stirring rate during the reaction
Fast reaction Yes, generally takes seconds or less No, usually takes hours or days
Precise control Yes, precise control over each step: seeding, growth and ceasing reaction No, lack control over seeding and growth
Reproducibility Medium High Low
Automation Yes, programmable equipment makes the process automatic No, usually require watching over the process
Low consumption of reagents Yes, owing to the scale effect No
Scale-up probability Low Moderate High, very easy to fabricate large quantity of products
Low cost If scaled up, yes; otherwise no When large quantity of products required, yes; otherwise, moderate
Harsh conditions Yes, with the enclosed environment No
R&D Pilot Studies Very suitable for the development of new materials and/or material screening Not suitable, low efficiency and no precise control