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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Expo Sci Environ Epidemiol. 2018 Sep 21;30(1):137–148. doi: 10.1038/s41370-018-0069-2

Table 5:

Association of sources in the NICU to a WQS index estimated using weights from significant NNNS scales.

Attention Habituation Handling Excitability Regulation Non-Optimal Reflexes
Relevant phthalate mixture (27) MEOHP MEHHP MECPP MEP MMP MECPP MEP MMP MEOHP MCPP MEP MEOHP MEP MEOHP MCPP MEP
Source of Exposure beta 95% CI p-value beta 95% CI p-value beta 95% CI p-value beta 95% CI p-value beta 95% CI p-value beta 95% CI p-value
PIV 0.45 −0.66, 1.56 0.419 0.64 −0.59, 1.87 0.299 0.44 −0.64, 1.52 0.419 0.51 −0.57, 1.59 0.352 0.49 −0.62, 1.60 0.383 0.45 −0.63, 1.53 0.406
Invasive respiratory support −0.53 −0.53, 1.59 0.324 0.41 −0.83, 1.65 0.512 0.89 −0.12, 1.90 0.083 0.88 −0.13, 1.88 0.086 0.64 −0.40, 1.69 0.222 0.90 −0.10, 1.90 0.077
Noninvasive respiratory support 1.87 0.23, 3.52 0.026* 2.30 0.53, 4.06 0.011* 2.15 0.59, 3.71 0.008* 2.05 0.49, 3.61 0.011* 1.89 0.27, 3.52 0.023* 2.01 0.45, 3.56 0.012*
Feeding tube −0.57 −1.94, 0.81 0.412 −0.42 −1.89, 1.05 0.573 −0.59 −1.91, 0.72 0.370 −0.53 −1.84, 0.79 0.427 −0.65 −2.02, 0.71 0.341 −0.55 −1.86, 0.76 0.406
Central line −0.71 −2.00, 0.59 0.279 −1.36 −2.87, 0.14 0.076 −0.48 −1.71, 0.76 0.445 −0.56 −1.80, 0.67 0.365 −0.48 −1.77, 0.80 0.457 −0.56 −1.80. 0.68 0.368
Incubator 1.16 −0.04, 2.27 0.042* 0.95 −0.21, 2.12 0.107 0.85 −0.24, 1.94 0.123 0.76 −0.33, 1.85 0.169 1.04 −0.08, 2.15 0.068 0.78 −0.30, 1.86 0.153
*

p <0.05

- WQS regression analyses included 10 of 15 phthalate monoesters measured, all those measured above the limit of detection in greater than 85% of specimens collected from the cohort. Models adjusted for the following covariates: gestational age at birth, status as small for gestational age at birth, and infant gender.

- MEOHP = mono(2-ethyl-5-oxohexyl) phthalate; MEHHP = mono(2-ethyl-5-hydrohexyl) phthalate; MECPP = mono(2-ethyl-5-carboxypentyl) phthalate; MEP = monoethyl phthalate; MMP = monomethyl phthalate; MCPP = mono(3-carboxypropyl) phthalate