Database	Time span	Search strategy
The Cochrane Hepato‐Biliary Group Controlled Trials Register	Date will be provided at review stage.	(((hepat* or liver) and (carcinom* or cancer* or neoplasm* or malign* or tumo*)) or hepatocellular caricoma or HCC) AND (((thermal or (radiofrequenc* or radio‐frequenc* or radio frequenc*) or microwave or laser* or high intensity focused ultrasound or cryo*) AND (ablati* or therap* or treat* or suger* or coag*)) OR cryoablati* or cryosuger* or RFA or RFTA or RFT or RFCA or MWA or HIFU) AND (((transcatheter or transarterial) and chemoemboli*) or TACE)
Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library	Latest issue	#1 MeSH descriptor: [Carcinoma, Hepatocellular] explode all trees #2 MeSH descriptor: [Liver Neoplasms] explode all trees #3 (((hepat* or liver) and (carcinom* or cancer* or neoplasm* or malign* or tumo*)) or hepatocellular caricoma or HCC) #4 #1 or #2 or #3 #5 MeSH descriptor: [Catheter Ablation] explode all trees #6 MeSH descriptor: [Ablation Techniques ] explode all trees #7 MeSH descriptor: [Cryosurgery] explode all trees #8 MeSH descriptor: [Laser Therapy ] explode all trees #9 MeSH descriptor: [High‐Intensity Focused Ultrasound Ablation] explode all trees #10 ((thermal or (radiofrequenc* or radio‐frequenc* or radio frequenc*) or microwave or laser* or high intensity focused ultrasound or cryo*) AND (ablati* or therap* or treat* or suger* or coag*)) OR cryoablati* or cryosuger* or RFA or RFTA or RFT or RFCA or MWA or HIFU #11 #5 or #6 or #7or #8 or #9 or #10 #12 MeSH descriptor [Embolization, Therapeutic] explode all trees #13 ((transcatheter or transarterial) and chemoemboli*) orTACE #14 #12 or #13 #15 #4 and #11 and #14 in trials
MEDLINE (PubMed)	1946 to the date of search	((((hepatocellular OR hepato‐cellular OR hepatic OR liver) and (carcinom* OR cancer OR neoplasm* OR malign* OR tumor)) OR hepatocellular carcinoma OR HCC) OR Carcinoma, Hepatocellular[MeSH] OR Liver Neoplasms[MeSH]) and ((((thermal OR (radiofrequenc* OR radio‐frequenc* OR radio frequenc*) OR microwave OR laser OR high intensity focused ultrasound) AND (ablati* OR therapy OR therapies OR treat* OR suger* OR coag*)) OR cryoablati* OR RFA OR rfta OR RFT OR rfca OR MWA OR hifu) OR Catheter Ablation[MeSH] OR Ablation Techniques[MeSH] OR Cryosurgery[MeSH] OR Laser Therapy[MeSH] OR High Intensity Focused Ultrasound Ablation[MeSH]) and ((((transcatheter OR transarterial) and chemoemboli*) OR TACE) OR Chemoembolization, Therapeutic[MeSH]) and ((randomized controlled trial[pt] OR controlled clinical trial[pt] OR randomized[tiab] OR placebo[tiab] OR clinical trials as topic[mesh:noexp] OR randomly[tiab] OR trial[ti]) NOT (animals[mh] NOT humans[mh]))
Embase (www.embase.com)	1974 to the date of search	#1 'liver cell carcinoma'/exp #2 ((hepat* or liver) and (carcinom* or cancer* or neoplasm* or malign* or tumo*)) or ‘hepatocellular caricoma’ or HCC #3 #1 or #2 #4 'radiofrequency ablation'/exp #5 'catheter ablation'/exp #6 'microwave thermotherapy'/exp #7 'cryoablation'/exp #8 'laser surgery'/exp #9 'high intensity focused ultrasound'/exp #10 thermal or (radiofrequenc* or radio‐frequenc* or radio frequenc*) or microwave or laser* or ‘high intensity focused ultrasound’ or cryo* #11 ablation* or therap* or treat* or suger* or coag* #12 #10 and #11 #13 cryoablati* or cryosuger* or RFA or RFTA or RFT or RFCA or MWA or HIFU #14 #4 or #5 or #6 or #7 or #8 or #9 or #12 or #13 #15 'chemoembolization'/exp #16 ((transcatheter or transarterial) and chemoemboli*) or TACE #17 #15 or #16 #18 #3 and #14 and #17 #19 random* or blind* or placebo* or 'meta‐analysis' #20 #18 and #19
LILACS (Bireme)	1982 to the date of search	(((hepat$ or liver) and (carcinom$ or cancer$ or neoplasm$ or malign$ or tumo$)) or hepatocellular caricoma or HCC) AND (((thermal or (radiofrequenc$ or radio‐frequenc$ or radio frequenc$) or microwave or laser$ or high intensity focused ultrasound or cryo$) [Words] and (ablati$ or therap$ or treat$ or suger$ or coag$)) OR cryoablati$ or cryosuger$ or RFA or RFTA or RFT or RFCA or MWA or HIFU) [Words] and (((transcatheter or transarterial) and chemoemboli$) or TACE) [Words]
Science Citation Index Expanded (Web of Science)	1900 to the date of search	#1 TS=(((hepat* or liver) and (carcinom* or cancer* or neoplasm* or malign* or tumo*)) or hepatocellular caricoma or HCC) #2 TS=(thermal or (radiofrequenc* or radio‐frequenc* or radio frequenc*) or microwave or laser* or high intensity focused ultrasound or cryo*) #3 TS=(ablati* or therap* or treat* or suger* or coag*) #4 #2 AND #3 #5 TS=(cryoablati* or cryosuger* or RFA or RFTA or RFT or RFCA or MWA or HIFU) #6 #4 OR #5 #7 TS=(((transcatheter or transarterial) and chemoemboli*) or TACE) #8 TS=(random* OR blind* OR placebo* OR meta‐analysis) #9 #1 AND #6 AND #7 AND #8
Conference Proceedings Citation Index – Science (Web of Science)	1990 to the date of search	#1 TS=(((hepat* or liver) and (carcinom* or cancer* or neoplasm* or malign* or tumo*)) or hepatocellular caricoma or HCC) #2 TS=(thermal or (radiofrequenc* or radio‐frequenc* or radio frequenc*) or microwave or laser* or high intensity focused ultrasound or cryo*) #3 TS=(ablati* or therap* or treat* or suger* or coag*) #4 #2 AND #3 #5 TS=(cryoablati* or cryosuger* or RFA or RFTA or RFT or RFCA or MWA or HIFU) #6 #4 OR #5 #7 TS=(((transcatheter or transarterial) and chemoemboli*) or TACE) #8 TS=(random* OR blind* OR placebo* OR meta‐analysis) #9 #1 AND #6 AND #7 AND #8
China National Knowledge Infrastructure	Date will be provided at review stage.	TI=('TACE' + '肝动脉化疗栓塞' + '栓塞') AND TI=('热消融' + '消融' + '射频消融' + 'RFA' + '微波消融' + 'MWA' + '氩氦刀消融' + '冷冻消融' + 'HIFU' + '高强度聚焦超声' + '超声消融' + '激光消融') AND TI=('肝癌' + '肝细胞癌') AND (AB=('随机' + '随机对照') OR FT=('随机' + '随机对照'))
Wanfang	Date will be provided at review stage.	主题: (TACE + "肝动脉栓塞" + "肝动脉化疗栓塞") * ("热消融" + "射频消融" + RFA + "微波消融" + MWA + "氩氦刀消融" + "冷冻消融" + HIFU + "高强度聚焦超声" + "超声消融" + "激光消融") * ("肝癌" + "肝细胞癌") * ("随机" + "随机对照")