Table 2.
Defect size (cm) | Nerve | Animal | Implant | Time | Outcome | Quotation | |
---|---|---|---|---|---|---|---|
Small animal models in nerve surgery without cell transplantation | |||||||
1 | 4.0 | Tibial nerve | Rat | Chondroitinase ABC processed nerve | 3 M | Higher numbers of regenerated axons compared to control | Neubauer et al. [32] |
2 | 6.0 | Sciaitic nerve | Rat | Allograft vs. autograft | 20 W | Superior regeneration in allograft group compared to control | Saheb-al-Zamani et al. [33] |
3 | 3.0, 5.0, 7.0 | Saphenous nerve | Rabbit | Autograft | 15 M | Decreasing regeneration with increasing defects size | Koller et al. [34] |
4 | 5.0 | Sciatic nerve | Rabbit | Muscle grafts | 4 M | Light regeneration in muscle grafts | Mligiliche et al. [35] |
5 | 10.0 | Sciatic nerve | Rabbit | Muscle grafts | 2 M | No regeneration | Hems et al. [36] |
Small animal models in nerve surgery with cell transplantation | |||||||
6 | 4.0 | Tibial nerve | Rabbit | Autologous vein with and without SC, Autograft as a control | 2 M | Axonal regeneration in Isograft group and Vessel filled with Schwann cells | Zhang et al. [37] |
7 | 1.0–6.0 | Peroneal nerve | Rabbit | Vein | – | Regeneration on 3.0 cm. Poor outcome on long distances | Strauch et al. [39] |
8 | 6.0 | Peroneal nerve | Rabbit | Vein | 4 M | Regeneration on full distance | Strauch et al. [38] |
9 | 4.0 | Ulnar nerve | Rat | ε-caprolactone-co-trimethylene carbonate filled with Schwann cells | 12 M | No regeneration, extended formation of neuroma | Sinis et al. [40] |
M month, W week