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. 2018 Dec 13;169(9):240–251. doi: 10.1007/s10354-018-0675-6

Table 2.

Small animal models in peripheral nerve surgery

Defect size (cm) Nerve Animal Implant Time Outcome Quotation
Small animal models in nerve surgery without cell transplantation
1 4.0 Tibial nerve Rat Chondroitinase ABC processed nerve 3 M Higher numbers of regenerated axons compared to control Neubauer et al. [32]
2 6.0 Sciaitic nerve Rat Allograft vs. autograft 20 W Superior regeneration in allograft group compared to control Saheb-al-Zamani et al. [33]
3 3.0, 5.0, 7.0 Saphenous nerve Rabbit Autograft 15 M Decreasing regeneration with increasing defects size Koller et al. [34]
4 5.0 Sciatic nerve Rabbit Muscle grafts 4 M Light regeneration in muscle grafts Mligiliche et al. [35]
5 10.0 Sciatic nerve Rabbit Muscle grafts 2 M No regeneration Hems et al. [36]
Small animal models in nerve surgery with cell transplantation
6 4.0 Tibial nerve Rabbit Autologous vein with and without SC, Autograft as a control 2 M Axonal regeneration in Isograft group and Vessel filled with Schwann cells Zhang et al. [37]
7 1.0–6.0 Peroneal nerve Rabbit Vein Regeneration on 3.0 cm. Poor outcome on long distances Strauch et al. [39]
8 6.0 Peroneal nerve Rabbit Vein 4 M Regeneration on full distance Strauch et al. [38]
9 4.0 Ulnar nerve Rat ε-caprolactone-co-trimethylene carbonate filled with Schwann cells 12 M No regeneration, extended formation of neuroma Sinis et al. [40]

M month, W week