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. 2019 May 28;9:7926. doi: 10.1038/s41598-019-44452-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma membrane penetration and dynamic localization of lipid nanocapsules. (A) Electron micrographs of PC3-M8 cells treated with 100 nM of empty LNC600 (upper panels) or 100 nM of LNC600-WS12 (lower panels) for different times (5 s, 30 s, 5 min and 30 min). Lipid Nanoparticles appeared as electron-dense spots located at the plasma membrane and are indicated by an arrow. (B) Bar graphs show the quantification of the data for empty LNC600 (Bi) or LNC600-WS12 (Bii) as µm of mobile or rigid plasma membrane at different timepoints after treatment with 100 nM of empty LNC600 or LNC600-WS12. (C) Bar plot showing the quantification of empty LNC600 or LNC600-WS12 in the rigid (Ci) and mobile (Cii) fractions of plasma membranes obtained from PC3-M8 cells at different timepoints after treatment with 100 nM of empty LNC600 or LNC600-WS12. *P < 0.05 (ANOVA, Tukey’s multiple comparisons test).