Fig. 4.

Outcome of Mtb infection in vaccinated macaques. a Macaques were monitored clinically for disease, and necropsied if humane endpoints were reached prior to the predetermined endpoint of the study (6 months post-challenge). The fraction of animals reaching humane endpoint are shown on the curve. The survival curve of each treatment group was compared against BCG using the log-rank test and the unadjusted p-values are reported. The total FDG activity in the lungs, as a marker of inflammation, was quantified. BCG alone was used as the comparator group for all analyses. b Unvaccinated macaques compared with BCG-vaccinated macaques; c macaques vaccinated with BCG and boosted with protein plus adjuvant compared to BCG alone; d macaques vaccinated with BCG and boosted rAd5(TB) or Ad5(empty) compared with BCG alone. A Kruskal–Wallis test was performed and uncorrected Dunn’s test p-values are reported in (b, c, d). Dots represent individual animals and lines represent medians in (b, c, d)