Fig. 6.

PET imaging correlates with bacterial burden. The total lung FDG activity correlates with total thoracic bacterial burden (lung + lymph node) at necropsy (a). The total lung FDG activity at 12 weeks post-infection correlates with bacterial burden at necropsy weeks to months later (b). The results of simple linear regression indicate that there is a positive association between the total CFU and the total lung inflammation at necropsy (R² = 0.6375, F = 103.8, p < 0.0001) and at 12 weeks post infection (R² = 0.5350, F = 65.6, p < .0001). Dots represent individual animals and dotted lines represent 95% confidence intervals