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. 2019 May 28;10:2350. doi: 10.1038/s41467-019-10359-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Working model for ENDOA2-mediated VEGFR2 endocytosis. ENDOA2-mediated VEGFR2 endocytosis controls EC migration independently of the CLATHRIN-mediated VEGFR2 endocytosis pathway. SLIT2-ROBO1 targets VEGFR2 to the ENDOA2-dependent internalization pathway via srGAP1, leading to downstream PAK/p38 activation and cell migration