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. 2019 May 28;9:7965. doi: 10.1038/s41598-019-43775-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of skull acoustic properties on simulated temperature rise (patient D). (a) Acoustic velocity curves as a function of HU. The maximum acoustic velocities at 2000 HU are ±10% of the maximum acoustic velocity used in this study. (b) Simulated temperature rises that resulted from using the acoustic velocity curves in (a). (c) Constant attenuation curves as a function of HU. The two constants are within the plausible range of attenuation values (Fig. 6b). (d) Simulated temperature rises that resulted from using the attenuation curves in (c).