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. 2019 May 22;9:398. doi: 10.3389/fonc.2019.00398

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Copyright © 2019 Zheng, Qi, Wu, Zhou, Yu, Li, Yu, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of circPCMTD1 promoted cell migration and invasion, while knockdown of cells inhibited cell migration and invasion. (A) Wound-healing assays showed that circPCMTD1 overexpression promoted migration of U251 cells, and silencing circPCMTD1 suppressed the cell migration. Statistical analysis of three independent experiments was performed. (B) Wound-healing assays showed that circPCMTD1 overexpression promoted migration of U118MG cells, and silencing circPCMTD1 suppressed the cell migration. Statistical analysis of three independent experiments was performed. (C) Transwell analysis showed circPCMTD1 overexpression promoted the migration of U251 and U118MG cells. Statistical analysis of three independent experiments was shown in panel. (D) Transwell analysis showed circPCMTD1 overexpression promoted the invasion of U251 and U118MG cells, Statistical analysis of three independent experiments was shown in panel. (E) Transwell analysis showed circPCMTD1 knockdown promoted the invasion of U251 cells. Statistical analysis of three independent experiments was shown in panel. (F) Transwell analysis showed the invasion was suppressed after circPCMTD1 knockdown in U118MG cells. Statistical analysis of three independent experiments was shown in panel. Data were expressed as mean ± SD. *P < 0.05, **P < 0.01 represents statistical difference, ***P < 0.001 represents statistical difference.