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. 2019 May 22;9:398. doi: 10.3389/fonc.2019.00398

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Copyright © 2019 Zheng, Qi, Wu, Zhou, Yu, Li, Yu, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of miR-224-5p on cells growth and proliferation. (A) The overexpressing efficiency of mir-224-5p in U251 and U118MG cells was detected by qRT-PCR. (B) The silencing efficiency of miR-224-5p in U251 and U118MG cellswas detected by qRT-PCR. (C,D) CCK8 assaysshowed overexpressing the miR-224-5p suppressed the cell viability in the U251 and U118MG cell line from 24 to 84 h. (E,F) CCK8 assays showed silencing the miR-224-5p upregulated the cell viability in the U251 and U118MG cell line from 24 to 84 h. ***p < 0.001, **P < 0.01, *P < 0.05, n = 4. (G,H) 24 h after transfection, the cell cycle was arrested to S/G2/M phase when upregulated the expression of miR-224-5p. Conversely, miR-224-5p stably silencing in U251 and U118MG cells exhibited a massive G1 phase upregulated compared with their control cells. t ***p < 0.001 vs. control group for mimic-NC, ###p < 0.001 vs. control group for inhibitor-NC, n = 4.