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. 2019 May 28;9:7956. doi: 10.1038/s41598-019-44339-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Difference in survival among the cases that remained as LA and LB in both conventional and intrinsic subtype and the cases switched from LA in conventional to LB in refined subtype for both TCGA (A,C) and METABRIC (B,D) cohorts. For the TCGA-BC cohort, two recommended³⁶ end points are used: progression-free interval (PFI) and disease-free Interval (DFI). For METABRIC cohort, both available end points are used: disease-specific survival (DSS) and overall survival (OS). P-value and the number of events ‘/’ number of cases are given in the legends of plots.