Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 28;9:7932. doi: 10.1038/s41598-019-44333-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Time course of the capsaicin-initiated inhibition of the ACh-induced NO-dependent vasodilator component. The experimental protocol of the results shown in A, B and C is depicted on the top of the figure. (A) Relaxation induced by 100 nM ACh in KCl-contracted mesenteric arteries in control conditions and 15 or 60 min after treatment with capsaicin (1 µM) or its vehicle for 20 min. ACh was applied in the presence of 10 µM indomethacin to prevent the interference of prostaglandins in the response. (B) NO production induced by successive ACh (100 nM) stimulations along the time in mesenteric arterial beds treated with capsaicin or the vehicle. (C) Relaxation induced by 300 nM SNAP, a NO donor, in KCl-contracted mesenteric arteries before (control) or 15 or 60 min after treatment with capsaicin or its vehicle. Values are means ± SEM. *P < 0.05 vs control by one-way ANOVA plus Dunnett post hoc test.