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. 2019 May 22;10:500. doi: 10.3389/fphar.2019.00500

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Copyright © 2019 Kossakowski, Schlicker, Toczek, Weresa and Malinowska.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of intravenous injection of cannabidiol (CBD) on heart rate (HR; A,D) and systolic (SBP; B,E) and diastolic (DBP; C,F) blood pressure in urethane-anesthetized normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. With one exception all doses of CBD were examined in separate animals. Changes were determined under the following conditions, i.e., in all rats (CONTROL); in rats with comparable basal values (for explanation, see text or legend to Table 1); when CBD 10 mg/kg was given after CBD 30 mg/kg; after vagotomy; and in the presence of capsazepine 0.4 mg/kg or its vehicle. Data are given as the means ± SEM of 5–22 rats. We used the t test for unpaired data (* and $) and the one-way analysis of variance (ANOVA) followed by the Dunnett post hoc test (#). *p < 0.05; **p < 0.01; ***p < 0.001 in comparison to the respective values in WKY; ^#p < 0.05; ^##p < 0.01; ^###p < 0.001 in comparison to the respective CONTROL group; ^$$p < 0.01; ^$$$p < 0.001 in comparison to the respective group treated with vehicle for capsazepine.