FIG 5.

Role of EPCR and ICAM-1 in P. falciparum-IE binding to 3D brain microvessels. (A to C) Percentage of binding of P. falciparum-IE in the presence of anti-EPCR MAb 252 or anti-ICAM-1 MAb 15.2 antibody. Percentage of binding is normalized to binding in the presence of IgG control antibody or the absence of antibody treatment. Bars represent mean ± standard error of the mean (SEM) (n = 4 to 5 independent biological replicates). Statistical analysis of binned regions in pairwise comparisons was determined by Mann-Whitney test and in multiple comparisons was corrected by a Kruskal-Wallis test.