FIG 4.

Treatment with an encochleated oral formulation of CAmB results in a similar cytokine milieu as that after treatment with amphotericin B in lungs of C. neoformans-infected mice. Groups of mice were inoculated as in Fig. 1B, after 1 week (Cn Infected) were treated with the indicated formulation daily (without 5FC), and were sacrificed after the indicated doses, and lung homogenates were assayed for the indicated cytokines. Uninfected mice served as controls (naive). n = 5 mice per group; *, P < 0.05; error bars, ±SD.