FIG 1.
(A) Time-activity curve (TAC) of 18F-DPA714 PET scan in SUV#1 shows different levels of total binding in different regions (SUV at equilibrium) with stable nonspecific binding (equilibrium after displacement). (B) TACs of the putaminal VOI in SIV#1 show decreased total binding at the last time point prior to necropsy (red line) compared to preinoculation (blue line) with relatively stable nonspecific binding. (C and D) SIV#1 (C) and SIV#3 (D) preinoculation and postinoculation, prenecropsy 18F-DPA714 PET scans (reflecting SUVT). While SIV#1 showed decreased uptake, SIV#3 showed increased uptake at the last time point. (E and F) Corresponding changes of CSF VL and BPND values for the same two animals over the course of their disease (green boxes reflect treatment [ART] courses).