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. 2019 May 15;27(10):2066–2074. doi: 10.1016/j.bmc.2019.04.002

Table 1.

Activity of covalent warheads with cysteine; data in triplicate.

Covalent Warhead graphic file with name fx1.gif
graphic file with name fx2.gif k = 8.38 × 10−5 s−1
t1/2 = 2.3 ± 0.1 h
graphic file with name fx3.gif k = 6.73 × 10−4 s−1
t1/2 = 17.2 ± 1.2 min