Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 24;12:3919–3931. doi: 10.2147/OTT.S201421

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Meng et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

Preparation of Tam-Gel achieves in vivo long-term release of tamoxifen from Tam-Gel in a nude mouse subcutaneous tumor model. Tam-Gel or Tam-Sol was injected into subcutaneous tumors, and tumor tissues were collected at the indicated time-points. Then, tamoxifen sustained in the tumor tissue samples at the indicated time points was determined by LC-MS/MS experiments. For the Tam-Gel injection group, representative LC-MS/MS maps are shown at (A) 0 hours, (B) 12 hours, (C) 24 hours, (D) 48 hours, and (E) 288 hours. For the Tam-Sol injection group, representative LC-MS/MS maps are shown at (F) 0 hours, (G) 12 hours, (H) 24 hours, and (I) 48 hours. (J) Sustained release curve of tamoxifen in Tam-Gel (mean±SD).

Abbreviation: LC-MS/MS, liquid chromatography–tandem mass spectrometry.