Skip to main content
. 2019 May 29;39(22):4323–4331. doi: 10.1523/JNEUROSCI.0364-19.2019

Figure 3.

Figure 3.

Dural application of IL-6 induces priming to dural CGRP in females, but not in males. Facial withdrawal thresholds were measured in female (A) and male (B) rats before and after administration of either 0.1 ng dural IL-6 (n = 10 females, n = 11 males) or vehicle pH 7.4 SIF (n = 9 females, n = 11 males). At 72 h after dural IL-6, all animals received a subthreshold dose of dural CGRP (0.1 pg). Two-way ANOVA indicated a significant effect of CGRP in the IL-6-treated group of females. The significant differences of the means for each group were determined by ANOVA followed by Bonferroni post hoc test (F(9,176) = 7.065; **p < .01, ***p < 0.001, ****p < 0.0001). These data are represented as means ± SEM.