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. 2019 May 22;10:585. doi: 10.3389/fphar.2019.00585

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Copyright © 2019 Zhang, Han, Zhao, Li, Jin and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRIB3 downregulation reduces KA-induced excitotoxic neuronal death in vitro. TRIB3 total mRNA (A) and protein (B) were detected after transfection with siTRIB3. (C) Apoptosis of cultured cortical neurons (positive NeuN) was analyzed using the TUNEL assay. (D) Activated caspase-3 was detected by immunofluorescence. Expression of GRP78 (E) and CHOP (F) in cultured neurons was detected by Western blot. *p < 0.05 vs. control. Control, control group; KA, KA-treated group; siNC+KA, siNC+KA-treated group; siTRIB3 + KA, siTRIB3 + KA-treated group.