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. 2019 May 22;10:585. doi: 10.3389/fphar.2019.00585

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Copyright © 2019 Zhang, Han, Zhao, Li, Jin and Qin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRIB3 downregulation inhibits the KA-mediated reduction of phospho-AKT. (A) Total AKT and phospho-AKT (Ser473) were detected by Western blotting. (B) Double immunofluorescence staining for TRIB3 and phospho-AKT. (C) Double immunofluorescence staining for TRIB3 and phospho-AKT in vitro. **p < 0.05. Control, control group; KA, KA-treated group; siNC+KA, siNC+KA-treated group; siTRIB3 + KA, siTRIB3 + KA-treated group.