Table 8.
Summary of docking analysis with ghrelin.
| Sr. No. | Ligand | Dock score | Interacting residues | Bond type | Bond angle |
|---|---|---|---|---|---|
| 1 | Niacin | −11.1374 | ALA 53 | HB | 2.36 |
| ASN 76 | HB | 1.85 | |||
| 2 | Ascorbic acid | −7.2393 | PRO 49 | HB | 2.15 |
| HB | 1.86 | ||||
| GLN 36 | HB | 1.77 | |||
| ALA 77 | HB | 2.18 | |||
| 3 | Riboflavin | −7.0131 | ALA 77 | HB | 2.40 |
| GLN 36 | HB | 1.68 | |||
| HB | 1.59 | ||||
| ASN 76 | HB | 1.62 | |||
| 4 | Thiamine | −4.7344 | GLN 36 | HB | 1.77 |
| ALA 77 | HB | 2.13 | |||
| HIE 32 | Pi-Pi Stacking | 5.33 | |||
| 5 | 8 nonynoic acid | 1.9189 | ASN 76 | HB | 1.84 |
| 6 | 9 Decynoic acid | 2.7981 | ALA 77 | HB | 2.13 |
| 7 | Methyl non-8-ynoate | 2.9037 | No interaction | ||
| 8 | Methyl Dec-9-ynoate | 4.0035 | |||
| 9 | Campesterol | 6.9115 | |||
| 10 | Methyl 8-oxooctadec-9-ynoate | 8.7284 | GLU 36 | HB | 2.20 |
| ASN 76 | HB | 1.92 | |||
| 11 | Methyl malvalate | 11.8293 | ALA 77 | HB | 2.18 |
| 12 | Methyl Sterculate | 12.0917 | No interaction | ||
| 13 | Beta sitosterol | 12.2015 | |||
| 14 | (9) Methyl (E)-11-methoxy-9-oxononadec-10-enoate | 13.2915 | |||
| 15 | Orlistat | 15.8166 | ASN 76 | HB | 1.65 |
| ALA 77 | HB | 2.20 | |||
Orlistat, as only standard drug used in market is used as standard reference for docking studies. Hence the docking result of orlistat in all tables is bold for ease of comparison.