Value of the data •Obesity declared as a disease by WHO and is the main cause of other many metabolic disorders which lead to mortality. •Literature explains multiple mechanisms involved in energy uptake and energy consumption, the control of which can help in maintaining energy balance and thus keeping obesity at large. •This article provides all dataset of protein structures to explore potential targets for obesity. •In-silico exploration of targets is the first step in drug design to understand the underlying mechanism of action of the identified drug molecule. •Many herbal medicines and food supplements are found to be beneficial in reducing body weight, although mode of action and identification of marker phytoconstituents is still not explored. •Docking of phytoconstituents to seven identified targets for obesity can pave a way towards identification of novel anti-obesity drug.