Table 2.
Comparison of clinical language features between FTLD-TDP and FTLD-Tau groups
| Language features | EARLY (0-3 years) | LATE (> 3 years) | ||||
|---|---|---|---|---|---|---|
| FTLD-TDP | FTLD-Tau | Sig. | FTLD-TDP | FTLD-Tau | Sig. | |
| Imp single-word retrieval | 11/11 (100) | 10/10 (100.0) | na | 8/8 (100.0) | 12/12 (100.0) | na |
| Imp naming | 9/10 (90) | 8/9 (88.9) | 1.000 | 8/8 (100.0) | 12/12 (100.0) | na |
| Imp sentence repetition | 5/9 (55.6) | 3/8 (37.5) | 0.637 | 2/5 (40.0) | 11/11 (100.0) | 0.018* |
| Nonfluent speech | 4/11 (36.4) | 9/10 (90.0) | 0.024* | 2/8 (25.0) | 11/12 (91.7) | 0.004* |
| Agrammatism | 4/11 (36.4) | 7/10 (70.0) | 0.198 | 1/8 (12.5) | 10/12 (83.3) | 0.005* |
| Dysarthria | 3/11 (27.3) | 5/10 (50.0) | 0.387 | 1/8 (12.5) | 8/12 (66.7) | 0.028* |
| Empty speech content | 2/11 (18.2) | 2/10 (20.0) | 1.000 | 6/8 (75.0) | 2/12 (16.7) | 0.019* |
| Semantic paraphasias | 5/11 (45.5) | 3/10 (30.0) | 0.659 | 5/8 (62.5) | 7/12 (58.3) | 1.000 |
| Phonemic paraphasias | 2/11 (18.2) | 5/10 (50.0) | 0.183 | 2/8 (25.0) | 10/12 (83.3) | 0.019* |
| Imp gramm compr | 6/7 (85.7) | 5/10 (50.0) | 0.304 | 3/8 (37.5) | 10/12 (83.3) | 0.062 |
| Imp single-word compr | 7/10 (70) | 2/9 (22.2) | 0.070 | 7/7 (100.0) | 5/12 (41.7) | 0.017* |
| Imp object knowledge | 5/9 (55.6) | 2/9 (22.2) | 0.335 | 6/6 (100.0) | 3/12 (25.0) | 0.009* |
| Surface dyslexia | 1/8 (12.5) | 1/9 (11.1) | 1.000 | 4/4 (100.0) | 2/7 (28.6) | 0.061 |
compr = comprehension; FTLD-Tau = frontotemporal lobar degeneration with inclusions of the tau protein; FTLD-TDP = frontotemporal lobar degeneration with inclusions of the transactive response DNA-binding protein 43; gramm = grammatical; Imp = impaired; Sig. = significance.
Categorical binary clinical features were compared between FTLD-TDP and FTLD-Tau groups using the Fisher’s Exact test independently of clinical phenotype. Significance values are reported in the table and significant results (p < 0.05) are indicated with an asterisk (*).