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EC50 and IC50 values of the sweet-taste receptor ligands
| EC50 (mM) | IC50 (mM) | ||
|---|---|---|---|
| D-tryptophan | Cyclamate | D-tryptophan (10 mM) + lactisole | |
| WT | 4.1 | 2.7 | 0.016 |
| R725A | 3.4 | 3.3 | 0.165 |
| R725E | 3.1 | NR | 0.065 |
| N737A | 4.2 | NR | NT |
| Y771L | 5.1 | NR | NT |
| W775F | NR | NR | NT |
| W775H | 4.1 | NR | NT |
WT, wild type. NR means that EC50 cannot be determined because the receptor is not responsive. NT means that the system has not been tested.
