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. 2019 May 5;20(9):2210. doi: 10.3390/ijms20092210

Figure 4.

Figure 4

(a) Optimized transition state geometries of PL-diclofenac prodrugs with 5 vs. 6 carbons linker, within human PLA2 (the protein structure was removed for simplicity); (b) Equilibrated structures of PL-diclofenac conjugates with linker lengths of 2- and 6- CH2 units in bee venom PLA2. Figure 4b is reproduced with permission from [25].