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. 2019 May 7;24(9):1765. doi: 10.3390/molecules24091765

Figure 2.

Figure 2

Rendition of a cardiomyocyte during ischemia and reperfusion depicting Na+-induced cytosolic and mitochondrial Ca2+ overload consequent to ischemia generating intracellular acidosis while the Na+-K+ pump is inhibited. Ch, channel; NBC, Na+-HCO3 co-transporter; NCX, Na+-Ca2+ exchanger; NHE-1, sodium– hydrogen exchanger isoform-1.