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. 2019 May 7;24(9):1765. doi: 10.3390/molecules24091765

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Left ventricular wall thickening during chest compression (CC) in an NaCl-treated pig (upper frames) but not in a cariporide-treated pig (lower frames), measured by transesophageal echocardiography at the end of diastole at baseline and between chest compressions (CC) at 2 and 8 min of CPR. (B) Progressive decreases in the coronary perfusion pressure (CPP) coincident with progressive left ventricular (LV) wall thickening in NaCl-treated pigs but not in cariporide-treated pigs. NaCl or cariporide (drug, 3 mg/kg) was given immediately before starting chest compression. Mean ± SEM. * p < 0.05, ^† p < 0.001 vs. cariporide by one-way ANOVA (Reproduced with permission from Ayoub et al. [14]).